Lumican-Mediated Fibroblast Differentiation in Skin Fibrosis - PubMed
6 hours ago
- #fibroblast differentiation
- #skin fibrosis
- #Lumican
- Lumican identified as a key regulator of fibroblast differentiation influencing skin fibrosis.
- Study integrates single-cell and spatial transcriptomics on fetal skin, adult skin, and keloids.
- Fibroblast gene expression analysis reveals five hub genes (BGN, COL6A1, FN1, LUM, TIMP1) increasingly expressed from fetal to fibrotic tissue.
- Lumican knockdown reverses keloid fibroblast differentiation and reduces collagen deposition.
- Findings suggest Lumican targeting could inhibit fibrosis and promote scarless healing.