Identification of Smmhc-expressing mesenchymal cells in orofacial bone at single-cell resolution - PubMed
5 hours ago
- #mesenchymal stem cells
- #single-cell RNA sequencing
- #orofacial bone
- Identification of Smmhc-expressing mesenchymal cells in orofacial bone using single-cell RNA sequencing (scRNA-seq).
- Discovery of a new population of Smmhc-expressing mesenchymal stem/stromal cells (MSCs) at the earliest stage of the progenitor lineage trajectory.
- Smmhc+ MSCs are multipotent, giving rise to osteoblasts, osteocytes, periodontal ligament (PDL) cells, and dental pulp cells.
- Ablation of Smmhc+ MSCs leads to impaired orofacial bone development and disrupted tissue homeostasis.
- Smmhc+ MSCs play a crucial role in craniofacial bone homeostasis by balancing osteogenesis and bone resorption.