African swine fever virus pI73R hijacks host mRNA to suppress interferon beta and reveals a druggable target for antiviral intervention - PubMed
5 hours ago
- #ASFV
- #interferon
- #antiviral
- ASFV pI73R protein suppresses cGAS-STING-mediated interferon beta (IFN-β) activation.
- pI73R binds to TBK1 and IRF3 mRNAs, promoting their nuclear retention and reducing IFN-β production.
- Silencing I73R increases IFN-β mRNA levels and enhances TBK1 and IRF3 protein levels in infected cells.
- A small-molecule compound, STL527159, disrupts pI73R-RNA interaction, restoring nuclear export and translation of TBK1 and IRF3 mRNAs.
- STL527159 significantly reduces ASFV infection in vitro, suggesting a potential antiviral drug target.