The Ca2+ sensor STIM1 promotes neuronal ferroptosis by regulating iron homeostasis to exacerbate brain injury after intracerebral hemorrhage - PubMed
3 months ago
- #STIM1
- #intracerebral hemorrhage
- #ferroptosis
- STIM1 is elevated in neurons after intracerebral hemorrhage (ICH) and correlates with poor prognosis in patients.
- Neuronal knockout of STIM1 in mice reduces brain tissue damage and neurological injury.
- STIM1 promotes neuronal ferroptosis by regulating iron homeostasis through interaction with transferrin receptor 1 (TFR1).
- S-IN-1, identified via virtual screening, inhibits STIM1-TFR1 interaction, protecting against neuronal ferroptosis and brain injury.
- The study provides insights into STIM1's role in ICH and identifies potential therapeutic targets.