Salivary MicroRNA Reflects Neurodevelopment and Oral Health Traits in Children With Autism - PubMed
4 hours ago
- #autism spectrum disorder
- #salivary microRNA
- #oral health biomarkers
- The study found 125 differentially expressed salivary microRNAs between children with ASD and healthy controls, indicating a distinct molecular profile.
- Children with ASD showed higher dental caries scores and poorer periodontal and behavioral outcomes compared to controls.
- miR-151a-3p and behavior were significant predictors of dental caries burden in a pooled analysis.
- Dysregulated miRNAs are linked to neurodevelopmental and immune pathways, suggesting shared influences on ASD and oral health.
- Salivary miRNAs could serve as non-invasive biomarkers for early ASD detection and personalized dental care.