The oscillatory biology of sleep: Linkage to dementia - PubMed
4 hours ago
- #dementia risk
- #sleep rhythms
- #glymphatic system
- Neuromodulators operate independently during wakefulness but synchronize into coordinated rhythms during sleep.
- Sleep-associated neuromodulator oscillations occur with a periodicity of about 50 seconds and are linked to cerebrospinal fluid flow.
- These neuromodulatory rhythms drive vasomotion that supports glymphatic clearance of metabolic waste, including amyloid-β and tau.
- Disruption of neuromodulator signaling, due to various disorders or drugs, impairs waste clearance and may increase dementia risk.