Distinct Proteomic Signatures Driving Progression of Sarcopenia: A Longitudinal Multicohort Study - PubMed
3 days ago
- #biomarkers
- #sarcopenia
- #proteomics
- Identified distinct proteomic signatures associated with sarcopenia progression using high-throughput proteomic analysis.
- Discovered 102 differentially expressed proteins between groups, with APOA1 downregulation and B2M elevation being significant markers.
- Validated seven robust protein signatures (LRG1, CST3, TIMP1, C2, ITIH1, AMBP, LYZ) consistently linked to sarcopenia components in both cohorts.
- Highlighted key pathways including LXR/RXR signaling, acute phase response, and complement cascade activation as central mechanisms in sarcopenia.
- Proposed potential targets for early detection and intervention strategies in sarcopenia based on validated biomarkers.