Efferocytosis in myocardial infarction: the regulatory core from inflammation resolution to cardiac repair - PubMed
8 hours ago
- #Myocardial Infarction
- #Efferocytosis
- #Cardiac Repair
- Efferocytosis plays a core role in orchestrating inflammation resolution and repair after myocardial infarction (MI) through precise spatiotemporal regulation.
- Dysfunction in efferocytosis (e.g., due to MerTK cleavage or CD47 upregulation) leads to sustained inflammation, failed repair, adverse remodeling, and heart failure.
- Therapeutic strategies aim to restore physiological balance by targeting 'don't-eat-me' signals, enhancing degradation, and reprogramming the immune microenvironment.
- A paradigm shift toward spatially targeted and temporally precise interventions is envisioned for effective efferocytosis-directed therapies.