Cellular memory of sub-lethal stress - PubMed
6 hours ago
- #cell death
- #chronic inflammation
- #cellular stress
- The abstract explores cellular memory as a consequence of sub-lethal stress.
- It notes that regulated cell death processes (apoptosis, pyroptosis, necroptosis, ferroptosis) are crucial for development and immunity.
- These processes involve potentially damaging activities like proteolysis and inflammation, traditionally leading to cell death.
- Sub-lethal activation of these pathways may instead cause sustained inflammation, senescence, or oncogenic transformation.
- The hypothesis presented is that sub-lethal activation of death programs, not just external stresses, could drive long-term tissue changes.
- This has significant implications for chronic inflammation, aging, and tumorigenesis.
- The article lists keywords such as aging, apoptosis, and inflammation.