GPI inactivation mediates pentose phosphate pathway flux switch-on inducing temozolomide resistance in glioma stem cell - PubMed
5 hours ago
- #chemoresistance
- #glioblastoma
- #pentose phosphate pathway
- Temozolomide (TMZ) resistance in glioblastoma (GBM) is a significant clinical challenge.
- Glioma stem cells (GSCs) maintain chemoresistance by increasing pentose phosphate pathway (PPP) flux.
- TMZ treatment suppresses glucose-6-phosphate isomerase (GPI) activity in GSCs.
- ATM, activated by TMZ-induced DNA damage, phosphorylates PLK1, leading to GPI inactivation.
- Targeting the ATM/PLK1/GPI axis with rigosertib may offer a therapeutic strategy.
- PLK1 expression and GPI pT215 levels could serve as markers for GBM.