Liver exerkine reverses aging- and Alzheimer's-related memory loss via vasculature - PubMed
3 days ago
- #Alzheimer's disease
- #cognitive rejuvenation
- #liver-brain axis
- Liver-derived exerkine GPLD1 reverses aging- and Alzheimer's-related memory loss by targeting brain vasculature.
- GPLD1 cleaves GPI-anchored proteins, with cerebrovascular TNAP identified as a key substrate affecting cognition.
- Inhibiting TNAP mimics GPLD1 benefits, restoring youthful hippocampal function and improving cognition in aged mice.
- GPLD1 or TNAP inhibition also ameliorates Aβ pathology and cognitive deficits in an Alzheimer's disease model.
- The study highlights the liver-to-brain exercise axis, mediated by blood factors, as crucial for cognitive rejuvenation.