ITGB1 Regulates Triple-Negative Breast Cancer Development by Modulating the Tumor Microenvironment - PubMed
3 months ago
- #TNBC
- #Tumor Microenvironment
- #Immunotherapy
- ITGB1 plays a critical role in triple-negative breast cancer (TNBC) development by modulating the tumor microenvironment (TME).
- In vivo CRISPR screens identified ITGB1 as a key regulator, influencing tumor-associated myeloid populations and immune cell infiltration.
- Suppression of ITGB1 promotes anti-tumorigenic myeloid cells and enhances CD4 and CD8 T cell infiltration, improving antitumor effects.
- A novel functional domain in ITGB1, distinct from known ligand-binding sites, was discovered to be essential for its pro-tumorigenic activity.
- An antibody targeting this domain significantly impaired TNBC progression, suggesting ITGB1 as a promising therapeutic target.
- The study provides insights into TNBC development mechanisms and proposes a unique strategy for ITGB1-targeted therapy.