Lipid droplet-induced T cell death sustains autoimmune tissue inflammation - PubMed
2 days ago
- #Autoimmunity
- #Pyroptosis
- #Lipid Droplets
- Autoimmunity in rheumatoid arthritis (RA) involves CD4+ T cell recruitment into synovial tissue.
- The inflamed synovium is identified as a lipid-rich environment, with oleic acid exacerbating synovitis.
- CD4+ T cells in lipid-rich environments undergo rapid lysis, releasing pro-inflammatory content.
- T cell lytic death involves gasdermin D and zDHHC5 sequestration to lipid droplets, leading to pyroptosis.
- Targeting lipid droplet formation or gasdermin activation suppresses synovitis effectively.
- Autoimmune CD4+ T cells are metabolically vulnerable and prone to pyroptosis in lipid-rich conditions.