Ancestry-specific genetics of amino acids and microbiota-related metabolites reveal causal effects on cardiometabolic disease in Chinese populations - PubMed
5 hours ago
- #Cardiometabolic Disease
- #Genetics
- #Microbiota
- Study focuses on ancestry-specific genetics of amino acids (AAs) and microbiota-related metabolites (MRMs) in Chinese populations.
- Large-scale GWAS of 28 serum AAs and 22 MRMs conducted in a cohort of 2953 Chinese individuals.
- Identified 33 metabolite-variant associations, with 22 being novel findings.
- Cross-ancestry comparison revealed several loci specific to East Asian ancestry.
- Colocalization and Mendelian randomization (MR) analyses established 49 causal relationships between metabolites and cardiometabolic diseases.
- Genetically predicted N-acetyltryptophan linked to increased risk of type 2 diabetes (T2DM).
- Distinct genetic regulation patterns observed between T2DM cases and healthy controls.
- Findings provide insights into ancestry-specific genetic determinants and their causal roles in cardiometabolic diseases.
- Study highlights dynamic gene-disease interplay and heterogeneity of effects.
- Ethics approval obtained from Ruijin Hospital, with no competing financial interests declared.