Vape flavoring chemicals and oral fibroblast viability - PubMed
4 hours ago
- #fibroblast_damage
- #oral_health
- #e_cigarette_toxicity
- E-cigarette flavoring chemicals, particularly aromatic aldehydes like cinnamaldehyde and vanillin, harm oral fibroblasts by increasing reactive oxygen species and causing oxidative damage.
- This oxidative stress leads to pro-inflammatory responses in fibroblasts, including elevated interleukin-8 and prostaglandin E2 secretion, contributing to tissue breakdown.
- Prolonged exposure to these flavoring agents results in increased apoptosis, reduced cell survival, and senescence in oral fibroblasts, impairing tissue repair capacity.
- Menthol and fruit flavors cause moderate effects, while unflavored e-cigarette aerosols show minimal toxicity, highlighting the specific risk of flavor additives.
- Flavored e-cigarettes may accelerate oral tissue deterioration, posing significant public health risks, especially among youth users, underscoring the need for regulation.