Granulomas microenvironment-guided sono-immunotherapy to treat and prevent recurrence of tuberculosis - PubMed
3 months ago
- #immunotherapy
- #tuberculosis
- #granuloma
- Granulomas microenvironment-guided sono-immunotherapy targets tuberculosis (TB) treatment and recurrence prevention.
- Bioinformatic analyses reveal suppressed innate immune responses in TB granulomas, contributing to treatment failure.
- Mannose-modified organic semiconducting nano-immunostimulants (manSNI) developed for precise TB sono-immunotherapy.
- manSNI generates reactive oxygen species (ROS) to eradicate Mycobacterium tuberculosis (M.tb) and promotes antigen release.
- Released antigens and TLR7 agonist R837 induce potent anti-TB immunity and long-lasting immune memory.
- This strategy shows promise for efficient TB control and prevention of relapse/reinfection.