Efficacy of topical tacrolimus for oral lichen planus: a retrospective cohort study stratified by cutaneous involvement - PubMed
5 hours ago
- #topical tacrolimus
- #oral lichen planus
- #cutaneous involvement
- Study on topical tacrolimus 0.1% gel efficacy for oral lichen planus (OLP), stratified by cutaneous involvement.
- Retrospective cohort of 120 biopsy-confirmed OLP patients, comparing tacrolimus vs. clobetasol propionate 0.05% gel over 8 weeks.
- Tacrolimus showed significant reductions in VAS pain and total atrophic area, with superior response rate (OR 3.2).
- Treatment effects were stronger in patients with cutaneous involvement, who had higher baseline severity.
- Adverse events were mild and transient, most commonly burning sensation.
- Topical tacrolimus may be useful as a second-line or steroid-sparing option, especially with concomitant cutaneous involvement.