NF-κB-activated fibroblasts orchestrate inflammaging and emergence of pro-inflammatory granzyme K+ T cells - PubMed
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- #fibroblasts
- #inflammaging
- #NF-κB
- Age-dependent NF-κB activation in tissue fibroblasts drives inflammaging, remodeling immune architecture.
- Fibroblast-specific NF-κB activation triggers a fibroblast-macrophage-T cell circuit, forming tertiary lymphoid structures in the lung.
- This circuit promotes the emergence of exhausted GZMK+CD8+ T cells, distinct from those in chronic viral infection, increasing susceptibility to acute lung injury.
- Depletion of GZMK+ T cells alleviates severe pneumonia-like conditions, mimicking those seen in elderly patients.