The incremental value of a novel immuno-inflammatory index (SIICI) in predicting sepsis after ureteroscopic lithotripsy: development and validation of a nomogram - PubMed
5 hours ago
- #sepsis
- #immuno-inflammatory-index
- #nomogram
- A novel immuno-inflammatory index (SIICI) was developed to predict sepsis after ureteroscopic lithotripsy (URSL).
- The study involved 803 patients and compared SIICI with other indices (SII, SIRI, PIV) using multivariate logistic regression.
- The 'Base + SIICI' model showed the highest discrimination (AUC = 0.863) and significant improvements in reclassification (NRI = 0.133) and discrimination (IDI = 0.058).
- The model performed well even in patients with negative preoperative urine cultures (AUC = 0.850).
- A visual nomogram and online calculator were developed for clinical application, showing good calibration (bootstrap-corrected AUC = 0.849).
- SIICI outperformed traditional indices (SII, SIRI, PIV) in predicting sepsis, aiding early risk stratification and proactive clinical decisions.