Effect of vitamin D3 supplementation on systemic inflammation and disease-specific markers in patients with autoimmune diseases: a comprehensive meta-analysis of randomized controlled trials - PubMed

6 hours ago

Vitamin D3 supplementation significantly increased serum 25(OH)D levels and showed modest anti-inflammatory effects, reducing CRP and IL-6.
Benefits were more pronounced with longer duration (≥6 months) and in patients with multiple sclerosis, but no significant effect was observed on key disease-specific outcomes like HbA1c in type 1 diabetes.
The meta-analysis supports vitamin D3 as a safe adjunctive therapy for autoimmune diseases, with effects influenced by treatment duration and specific disease type, though significant heterogeneity was noted across studies.

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