TRIM25 promotes antiviral innate immune response by stabilizing IRF7 and its nuclear translocation - PubMed
17 hours ago
- #TRIM25
- #IRF7
- #Antiviral Innate Immunity
- Duck TRIM25 promotes antiviral innate immunity by stabilizing IRF7 and facilitating its nuclear translocation.
- TRIM25 acts as an E3 ubiquitin ligase, catalyzing K27-linked polyubiquitination of IRF7 at lysine 46 to enhance IRF7 stability.
- TRIM25 also stabilizes IRF7 independently of its ligase activity by antagonizing SOCS1-mediated degradation.
- TRIM25-driven signaling occurs independently of RIG-I activation and compensates for the absence of IRF3 in avian species.
- Overexpression of TRIM25 increases IFN-β production and restricts replication of multiple RNA viruses in duck cells and ducklings.