Diagnostic Criteria and Management of MELAS and Stroke-Like Episodes: Consensus-Based Statements - PubMed
5 hours ago
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- #MELAS
- #diagnostic criteria
- MELAS is a rare multisystem mitochondrial disorder characterized by stroke-like episodes (SLE) and clinical heterogeneity.
- Consensus defines MELAS as a clinical syndrome with one or more SLE due to mitochondrial dysfunction, typically from the m.3243A>G variant.
- Terms like 'MELAS-like' or 'MELAS spectrum' are discouraged to avoid inconsistency.
- The efficacy of supplements like L-arginine, coenzyme Q10, and vitamins remains unproven and needs clinical trial validation.
- Prompt antiseizure medication is recommended during SLE, with intravenous corticosteroids potentially beneficial acutely.
- Multidisciplinary management is endorsed for neurological, neuropsychiatric, and systemic complications.
- Consensus aims to harmonize clinical practice and guide future research for MELAS and SLE diagnosis and management.