Multiomic and Longitudinal Dissection of Immune Dynamics Associated with Parkinsonism after Ciltacabtagene Autoleucel Therapy - PubMed
5 hours ago
- #Multiomic immune dynamics
- #Parkinsonism
- #CAR T-cell therapy
- A fatal case of parkinsonism occurred after treatment with ciltacabtagene autoleucel CAR T-cell therapy.
- Longitudinal multiomic analysis of CSF and peripheral blood over 6 months revealed biphasic immunologic dynamics.
- Early phase involved selective influx of CD4+ CAR T cells and endothelial dysfunction before clinical parkinsonism.
- Second phase started with a local inflammatory process in CSF, leading to blood-brain barrier disruption.
- Increased CSF/serum albumin ratio coincided with influx of CAR and cytotoxic non-CAR T cells, causing neuronal injury.