A protein adaptor mediating Ap4A-dependent control of protein acetylation - PubMed
4 hours ago
- #protein acetylation
- #Bacillus subtilis
- #Ap4A
- Reversible lysine acetylation is a conserved post-translational modification involved in cellular processes like metabolism and gene expression.
- The study identifies AcuB as an Ap4A-regulated deacetylation inhibitor in Bacillus subtilis, controlling the HDAC-like protein AcuC.
- Ap4A binds to the CBS domain of AcuB, stabilizing it and enhancing inhibition of AcuC, linking stress response to protein acetylation and acetyl-CoA biosynthesis.