Inhibition of DDX5-Mediated G-Quadruplex Unwinding in the β-Catenin 5'-UTR by Magnesium Isoglycyrrhizinate Alleviates Chemotherapy-Induced Intestinal Injury - PubMed
5 hours ago
- #chemotherapy
- #intestinal injury
- #DDX5
- Magnesium isoglycyrrhizinate (MIG) alleviates chemotherapy-induced intestinal injury by enhancing epithelial barrier integrity.
- MIG binds to RNA helicase DDX5, which destabilizes the G-quadruplex structure in the β-catenin 5' untranslated region, suppressing β-catenin production.
- MIG acts as a DDX5 inhibitor, restoring β-catenin expression and barrier integrity in a dose-dependent manner.
- MIG outperforms the DDX5 inhibitor supinoxin in mitigating intestinal damage in vivo.
- The study identifies the DDX5/CTNNB1 axis as a targetable pathway for treating chemotherapy-induced barrier dysfunction.