Glioblastoma-secreted C1QL1 orchestrates tumor microtube expansion and neural synaptic pruning to drive malignant synapse formation and recurrence - PubMed
5 hours ago
- #Glioblastoma
- #Synaptic Pruning
- #Rac1 Inhibitor
- Glioblastoma (GBM) cells form malignant synapses on tumor microtubes (TMs), promoting infiltrative growth and recurrence.
- Glioma-secreted C1QL1 acts as a key messenger for glioma-neuron and glioma-glioma crosstalk, driving TM expansion and malignant synapse formation.
- C1QL1 binds to receptor BAI3 on neurons and GBM cells, activating Rac1-mediated cytoskeleton rearrangement to prune normal synapses and promote TM outgrowth.
- A first-in-class Rac1 inhibitor rescues C1QL1-mediated synaptic pruning, inhibiting TMs and malignant synapses to impede glioma recurrence.
- The study highlights a therapeutic strategy targeting both TMs and glioma-induced synaptic pruning to combat GBM recurrence.