Actin depolymerization promotes axon regeneration by restoring axonal mitochondrial transport in mouse models of optic neuropathy - PubMed
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- #axon regeneration
- #mitochondrial transport
- #actin depolymerization
- Actin depolymerization promotes axon regeneration in mouse models of optic neuropathy.
- Gelsolin (Gsn) and other actin regulatory molecules enhance optic nerve regeneration and retinal ganglion cell (RGC) protection.
- AAV-mediated gene expression or small molecule delivery supports regeneration in optic nerve crush and glaucoma models.
- Actin depolymerization reduces F-actin in axon shafts and enhances mitochondrial transport in RGC axons.
- Latrunculin B promotes axon outgrowth in both mouse and human RGCs by targeting this mechanism.
- Elevated F-actin levels were found in aqueous humors of severe glaucoma patients, highlighting translational potential.