3D printed HAMA/GelMA/lignosulfonate hydrogel integrating oxygen-releasing and antioxidative modules for liver regeneration - PubMed
6 hours ago
- #3D Bioprinting
- #Liver Regeneration
- #Hydrogel
- Development of a multifunctional polysaccharide-based hydrogel for liver regeneration using sodium alginate (SA), sodium lignosulfonate (SL), and 3D bioprinting technology.
- Integration of FH1@SA microspheres and CaO2@ZIF-8@SL nanoparticles to reconstruct the hepatic microenvironment with oxygen generation, antioxidant activity, and anti-inflammatory modulation.
- FH1@SA microspheres enable sustained release of FH1, aiding hepatocyte adaptation to hypoxia and promoting functional recovery.
- CaO2@ZIF-8@SL nanoparticles provide controlled oxygen release and pH-responsive degradation, while lignosulfonate scavenges reactive oxygen species and mitigates inflammatory stress.
- The 3D-printed hydrogel exhibits favorable mechanical strength, injectability, and cytocompatibility, supporting hepatocyte proliferation and tissue regeneration.
- The hydrogel offers a synergistic strategy for hepatic repair by relieving hypoxia and oxidative stress, promising for bioartificial liver construction and liver injury treatment.