Integrating host-microbiota metabolic networks: how aromatic amino acids shape immune homeostasis and affect disease progression - PubMed
4 hours ago
- #gut microbiota
- #aromatic amino acids
- #immune homeostasis
- Aromatic amino acids (AAAs) are metabolized by both host and gut microbiota, producing metabolites that influence immune responses.
- These metabolites affect various immune cells, including dendritic cells, macrophages, T cells, and B cells, through receptors and epigenetic changes.
- The metabolic network involving AAAs is best viewed as an integrated system between host and microbiota, not as separate compartments.
- Dysregulation in AAA metabolism pathways contributes to diseases like inflammatory bowel disease and infectious diseases.
- Therapeutic strategies targeting the microbiota-metabolite-immune axis are emerging for precision interventions.