Single-cell multi-omics analysis reveals two molecular subtypes of human male breast cancer with distinct neuroendocrine and immune characteristics - PubMed
a day ago
- #Male Breast Cancer
- #Neuroendocrine Subtype
- #Single-Cell Analysis
- Single-cell multi-omics analysis identified two molecular subtypes of human male breast cancer (MBC) with distinct neuroendocrine (NE) and immune characteristics.
- MBC with high NE scores shows aggressive clinical features like lymph node metastasis and vascular invasion, and is classified as a 'cold tumor' potentially unsuitable for immunotherapy.
- A key transcription factor, DLX2, was identified as regulating NE features, while cell-cell communication involving NPY+ and NPY1R+ cells may promote these features.
- BCL2 is suggested as a potential therapeutic target for MBC with NE features, offering new insights for diagnosis and treatment.