Mechanistic role of gut microbiota metabolites in hypertension-insomnia comorbidity via integrated network pharmacology and molecular dynamics - PubMed
5 hours ago
- #Insomnia
- #Hypertension
- #Gut microbiota
- Gut microbiota metabolites play a significant role in the comorbidity of hypertension and insomnia.
- The study identified 278 gut microbial metabolites and their targets, with 408 common targets between hypertension and insomnia.
- Key findings include IL6 and PPARG as central hubs in the PPI network, and the IL-17 signaling pathway as crucial.
- Molecular docking showed strong binding of 3-indolepropionic acid to IL6, supported by stable molecular dynamics simulations.
- Butyrate and 3-indolepropionic acid were identified as promising metabolites with no hepatotoxicity or cardiotoxicity.
- The study suggests IL-17 inhibition and microbial metabolite supplementation as potential treatments for hypertension-insomnia comorbidity.