Single-cell profiling of the subgingival bacteria reveals transcriptional heterogeneity and niche-specific programs - PubMed
a day ago
- #subgingival bacteria
- #single-cell RNA sequencing
- #periodontitis
- Single-cell RNA sequencing framework developed for profiling subgingival bacteria.
- Study analyzed 133,458 cells across 285 species, identifying 57 core active species grouped into eight functional clusters.
- Health-associated bacterial subpopulations decline in periodontitis, showing shifts in metabolic activities.
- Keystone pathogens like T. denticola and P. gingivalis exhibit species-specific metabolic profiles.
- P. intermedia has a proteolytic subpopulation more prevalent in periodontitis.
- Findings provide insights into periodontitis pathogenesis and potential for precision diagnostics and therapies.