15-PGDH inhibition promotes muscle repair and strength recovery during GLP-1 receptor agonist-induced weight loss - PubMed
4 hours ago
- #Weight Loss Therapy
- #15-PGDH Inhibition
- #Muscle Regeneration
- Inhibition of 15-PGDH enhances muscle repair and strength recovery during GLP-1 receptor agonist weight loss therapy.
- Semaglutide, a GLP-1 agonist, reduces muscle mass but preserves function in obese mice; it can impede regenerated myofiber growth after injury.
- Co-treatment with a 15-PGDH inhibitor stimulates muscle stem cells, promotes myofiber growth, and improves strength without affecting weight loss.