Cell type-specific enhancers regulate IL-22 expression in innate and adaptive type 3 lymphoid cells - PubMed
5 hours ago
- #lymphoid cells
- #IL-22
- #enhancers
- IL-22 is a key cytokine for type 3 lymphoid cells, including Th17/22 and ILC3, involved in epithelial homeostasis and pathogen defense.
- Two enhancers, E22-1 and E22-2, regulate IL-22 expression differently in Th17/22 and ILC3 cells.
- E22-2 is specific to ILC3s due to Runx3 sites and lacks a functional RORγt motif, while E22-1 functions in both cell types.
- Both enhancers are essential for protection against Citrobacter rodentium infection and IL-22-mediated psoriasis.
- The study highlights distinct cis-regulatory elements in Th17/22 and ILC3 cells for IL-22 expression modulation.