Simulated microgravity induces cerebral dysfunction by disturbing protective microbiota-metabolite-microglia signaling across the gut‒brain ax is - PubMed
2 months ago
- #gut-brain axis
- #neuroinflammation
- #microgravity
- Simulated microgravity (SMG) leads to chronic behavior disorders and cognitive deficits via a microbiota-metabolite-brain axis.
- Fecal microbiota transplantation (FMT) from SMG-treated rats to normal gravity (NG) recipients induces anxiety-like behaviors and spatial working memory disturbances.
- SMG alters gut microbiota to a proinflammatory state, increasing Proteobacteria and decreasing linoleic acid (LA) and its metabolites.
- LA normally blocks inflammatory microglial activation by interacting with STAT1 and inhibiting its phosphorylation.
- Proteobacteria, especially Pseudomonas aeruginosa, consume LA under SMG, disrupting CNS immune homeostasis.
- Dietary LA supplementation mitigates SMG-induced neuroinflammation and cognitive impairment.
- The study suggests LA replenishment as a strategy to improve brain function during spaceflight.