Prognostic value of baseline circulating tumor DNA levels in metastatic castration-resistant prostate cancer: a systematic review and meta-analysis - PubMed
5 hours ago
- #biomarker
- #circulating tumor DNA
- #prostate cancer
- Elevated baseline ctDNA levels in mCRPC are significantly associated with worse survival outcomes, including OS, PFS, rPFS, and PSA-PFS.
- Subgroup analyses confirm the negative prognostic impact of high ctDNA levels on OS across different detection methods, treatments, and stratification strategies.
- The study supports ctDNA as a noninvasive, clinically meaningful biomarker for risk stratification and therapeutic decision-making in mCRPC.