GPER1 reduces skin inflammation by inhibiting keratinocyte proliferation - PubMed
5 hours ago
- #psoriasis
- #GPER1
- #keratinocyte proliferation
- GPER1 signaling is downregulated in psoriatic skin and negatively correlates with inflammation and keratinocyte proliferation.
- Gper1 deficiency in a zebrafish model leads to increased keratinocyte proliferation and neutrophil infiltration.
- Pharmacological inhibition of cell proliferation reduces keratinocyte aggregates and neutrophil infiltration without affecting NF-κB activation.
- Gper1 overexpression in basal keratinocytes, but not in neutrophils, rescues skin inflammation, indicating a cell-autonomous effect.
- Epithelial cell proliferation appears to facilitate immune cell infiltration into inflamed tissue.
- GPER1 is identified as a negative regulator of keratinocyte hyperproliferation and skin inflammation, suggesting potential therapeutic applications for psoriasis.