Molecular mechanism of menthol-induced TRPV5 channel inhibition - PubMed
7 hours ago
- #TRPV5
- #menthol
- #calcium homeostasis
- TRPV5 channels are crucial for calcium homeostasis and linked to various pathophysiological conditions.
- Menthol, a monoterpene used for pain and inflammation, inhibits TRPV5 channels.
- Electrophysiology experiments show menthol blocks ion conduction via a slow blocker mechanism.
- Cryo-EM structure reveals menthol interacts with W583, a residue important for channel function.
- Menthol could be a scaffold for developing TRPV5-targeting modulators.