Research Progress on Platelet-Rich Plasma (PRP) in the Treatment of Androgenetic Alopecia - PubMed
5 hours ago
- #Androgenetic Alopecia
- #Platelet-Rich Plasma
- #Hair Restoration
- Androgenetic alopecia (AGA) is a common cause of progressive hair loss, impacting quality of life.
- Current treatments like minoxidil, finasteride, and hair transplantation have variable efficacy and potential side effects.
- Platelet-rich plasma (PRP) is an autologous preparation rich in platelets and growth factors, emerging as a regenerative option for hair restoration.
- PRP promotes hair follicle regeneration through angiogenesis and activation of signaling pathways like Wnt/β-catenin, MAPK, Akt/ERK, and Notch.
- Clinical trials show PRP improves hair density, thickness, and patient satisfaction, especially when combined with minoxidil, microneedling, or laser therapy.
- Adverse effects of PRP are mild and transient, such as localized pain or erythema.
- Heterogeneity in PRP preparation protocols (centrifugation, activation, delivery) leads to inconsistent study outcomes.
- PRP is a promising, safe, and minimally invasive therapy for AGA, but standardized protocols and large-scale studies are needed for long-term efficacy confirmation.