Characterizing the effects of genetic liability to autoimmune conditions on pregnancy outcomes using Mendelian randomization - PubMed
5 hours ago
- #Pregnancy outcomes
- #Mendelian randomization
- #Autoimmune conditions
- Study explores causal effects of genetic liability to autoimmune conditions on pregnancy outcomes using Mendelian randomization.
- Higher genetic liability to Hashimoto's thyroiditis increases risks of hypertensive disorders of pregnancy (HDP) and preterm birth but is protective against large-for-gestational-age.
- Type 1 diabetes and systemic lupus erythematosus genetic liabilities increase preterm birth risk.
- Rheumatoid arthritis genetic liability raises HDP risk, while ankylosing spondylitis genetic liability reduces it.
- No robust effects found for multiple sclerosis, systemic sclerosis, coeliac disease, inflammatory bowel disease, and psoriasis.
- Findings suggest immune mechanisms underlying these relationships need further exploration for prevention targets.