Drug-induced psoriasis following sacubitril/valsartan: a case report and literature review - PubMed
3 hours ago
- #adverse drug reaction
- #psoriasis
- #sacubitril/valsartan
- Drug exposure can trigger or worsen psoriasis, including some cardiovascular drugs.
- A middle-aged man developed psoriasis after taking sacubitril/valsartan; symptoms improved after stopping the drug and using topical steroids, but returned when the drug was re-started.
- The patient had a history of psoriasis with nifedipine use, which improved after switching to olmesartan.
- The proposed mechanism involves sacubitril enhancing natriuretic peptides, possibly leading to increased angiotensin II, which may contribute to psoriasis development.
- This is the first reported case linking psoriasis to sacubitril/valsartan, highlighting a need for caution in patients with psoriasis history or HLA-Cw*0602 allele.
- Further research is needed to confirm the mechanism of sacubitril-induced psoriasis.