CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly - PubMed
6 hours ago
- #hepatic steatosis
- #nuclear pore complex
- #lipid metabolism
- CLCC1 is identified as a regulator of neutral lipid storage and secretion in hepatocytes.
- Loss of CLCC1 leads to hepatic steatosis in mice and large lipid droplets in hepatoma cells.
- CLCC1 knockout causes lipid droplets to accumulate in the endoplasmic reticulum lumen, resembling lipoproteins.
- CLCC1 deficiency results in nuclear membrane herniations and reduced nuclear pores.
- CLCC1 has a domain homologous to yeast Brl1 and Brr6, involved in nuclear envelope fusion.
- Molecular dynamics simulations suggest CLCC1 mediates membrane bending and fusion.
- CLCC1 is proposed to facilitate hepatic neutral lipid flux and nuclear pore complex assembly.