Hepatitis B Virus Promotes Hepatocellular Carcinoma Progression by Disrupting NSUN2/YBX1-mediated m5C Modification of PTEN mRNA - PubMed
5 hours ago
- #RNA Methylation
- #Hepatitis B Virus
- #Hepatocellular Carcinoma
- HBV promotes hepatocellular carcinoma (HCC) progression by disrupting m5C modification of PTEN mRNA.
- HBV reduces m5C modification on PTEN mRNA, particularly at a critical site (chr10:89717756).
- NSUN2 (writer) and YBX1 (reader) stabilize PTEN mRNA in an m5C-dependent manner, which HBV disrupts.
- Overexpression of NSUN2 or YBX1 counteracts HBV-driven cancer cell proliferation, migration, and invasion.
- HBV small surface antigen (HBsAg) and X protein (HBx) downregulate NSUN2 and YBX1, suppressing PTEN.
- HBV-associated reduction in NSUN2 is observed in HBV-Tg mice, infected hepatocytes, and clinical HCC samples.
- The NSUN2/YBX1/PTEN axis is a potential therapeutic target for HBV-associated HCC.