Evolutionary convergence and divergence of hippocampal cytoarchitecture between rodents and primates revealed by single-cell spatial transcriptomics - PubMed
5 hours ago
- #hippocampus
- #evolution
- #transcriptomics
- Study uses single-cell spatial transcriptomic analysis and single-nucleus RNA sequencing to create transcriptome-based atlases for macaque, marmoset, and mouse hippocampus.
- Cross-species comparison reveals primate- and lamina-specific glutamatergic cell types in the subicular complex.
- Enrichment of VIP-expressing GABAergic cells observed from mice to primates, including humans.
- Reduced transcriptomic differences between CA3 and CA4 subregions found in the study.
- Distinct longitudinal distributions of various cell types and ion-channel gene expression correlate with electrophysiological properties in CA3, CA4, and CA1 neurons.
- Findings provide molecular and cellular insights into the evolution and function of the hippocampus.