Vaccine-induced antibodies can limit Salmonella infection in the absence of complement or macrophages - PubMed
6 hours ago
- #vaccine
- #Salmonella
- #antibodies
- Vaccine-induced antibodies can limit Salmonella infection without complement or macrophages.
- OMV-induced antibodies promote Salmonella uptake by macrophages in the spleen and liver.
- Monocytic cells help prevent antigen dissemination, as shown by clodronate liposome depletion.
- OMV immunization protects against Salmonella in mice deficient in C1q, C4, or C5, but not C3.
- C3-deficient mice show impaired germinal center and plasma cell responses post-immunization.
- Adoptive transfer of immune sera reduces bacterial burdens in C3-deficient mice.
- Antibodies alone are sufficient to promote bacterial capture by macrophages in vitro.
- Complement (C1q, C3) enhances bacterial uptake, but C5 does not.
- Antibodies, complement, and macrophages work redundantly to control Salmonella infection.
- Findings highlight the importance of antibodies in limiting bacterial spread and combating AMR.