The landscape of tissue-resident microbiota across normal, polyp, and colorectal cancer tissues - PubMed
5 hours ago
- #microbiota
- #tumor microenvironment
- #colorectal cancer
- Study examines tissue-resident microbiota (TRM) in normal, polyp, and colorectal cancer (CRC) tissues.
- Analyzed 1134 clinical specimens to define microbial profiles across different colorectal tissue types.
- Found distinct microbial community compositions in normal, polyp, and CRC samples.
- Microbial signatures can distinguish tissue categories and reflect local tumor microenvironment differences.
- Intratumoral microbiota composition showed minimal variation across tumor stages and no association with clinical outcomes.
- Provides foundational insights for future research on TRM's biological roles in CRC.