Tissue-Conforming Organoselenium Hydrogel with Microphase-Controlled Acylhydrazone Crosslinking Kinetics Expedites Diabetic Wound Healing by Inhibiting AGE-RAGE Pathways - PubMed
6 hours ago
- #redox homeostasis
- #diabetic wound healing
- #organoselenium hydrogels
- Development of a tissue-conforming organoselenium hydrogel (TCOH) for diabetic wound healing.
- TCOH extends acylhydrazone crosslinking kinetics via microphase-separated organoselenium polymer (OSP).
- Effective restoration of redox homeostasis, enhanced angiogenesis, and immune microenvironment reprogramming by promoting M2 macrophage polarization.
- Transcriptomic and Western Blot analyses confirm suppression of AGE-RAGE and NF-κB signaling pathways.
- Accelerated wound closure, improved collagen deposition, and functional tissue regeneration demonstrated.
- Potential therapeutic platform for redox- and AGE-related chronic diseases.