Primary cilia promote cardiac fibrosis and limit heart function after myocardial infarction - PubMed
3 hours ago
- #cardiac fibrosis
- #myocardial infarction
- #primary cilia
- Primary cilia on cardiac fibroblasts play a key role in promoting fibrosis after myocardial infarction (MI).
- Deletion of cardiac fibroblast cilia reduces fibrosis and improves cardiac function post-MI, suggesting cilia act as a signaling hub for fibrotic responses.
- Following MI, cardiac fibroblasts proliferate, differentiate into myofibroblasts, and produce excessive collagen and ECM, leading to fibrosis that can both weaken heart function and prevent rupture.