Adaptable sliding hydrogels enable pericellular pocket formation while enhancing MSC chondrogenesis and survival in 3D - PubMed
6 hours ago
- #Chondrogenesis
- #Tissue Engineering
- #Mechanotransduction
- The study introduces adaptable sliding hydrogels (ASG) with tunable stress relaxation and plasticity as a novel niche for mesenchymal stromal cells (MSCs) to study chondrogenesis.
- ASG enables pericellular pocket formation, promoting rapid and robust cartilage formation and enhancing long-term MSC survival in 3D.
- Mechanistically, ASG facilitates matrix remodeling, integrin signaling, nuclear dynamics, and extracellular matrix deposition and reorganization.
- The hydrogels mimic dynamic mechanical cues of the native extracellular matrix without confounding biochemical influences.