Glymphatic system impairment in neurological disorders: potential mechanisms and therapeutic targets - PubMed
5 hours ago
- #Glymphatic System
- #Therapeutic Targets
- #Neurological Disorders
- The glymphatic system is a brain-wide clearance pathway that removes neurotoxic waste through glial-dependent perivascular networks, using aquaporin-4 (AQP4) channels on astrocytic end-feet.
- Glymphatic dysfunction is both a consequence and driver of neurological disorders, creating a pathological feedback loop through waste accumulation and disease progression.
- Key modulators of the glymphatic system include sleep-wake rhythms, arterial pulsatility, and aging, influencing its functional architecture from CSF influx to efflux.
- Therapeutic interventions being explored target AQP4 modulation and non-invasive physical approaches, aiming to shift from symptomatic management to disease modification.